Figure 5.
Example QT clock plots of individual patients (blue line) in reference to the healthy QTc range (green area as defined in Figure 2) for three different subjects: healthy 27 year-old (left panel), 64 year-old LQT1 patient with non-C-loop mutation (middle panel), and 1 year-old LQT2 patient with pore missense mutation (right panel). All subjects are female, and none are on beta blockers. The red area marks the QTc>500ms zone. The individual plottings are median-filtered beat-to-beat QTc values. The plots emphasize how the proposed “QTc clock” enables the physician to quickly identify periods of prolonged QTc, e.g. nighttime for the LQT2 patient.