Fig. 1.

Pedigree of UK family with 7 cases of melanoma in which the c.−57 T>G TERT promoter variant was reported in 2 affected cases. Both tested samples carried the variant allele. MM shows diagnosis of first malignant melanoma. <n (>n) indicates first diagnosis before (after) age n years. BCC indicates basal cell carcinoma. + symbol indicates germline sample carried c.−57 T>G variant. Other samples were not available for testing