Table 1.
Brain regions evaluated in the case review
| Brain region | Stains/IHC | ||||
|---|---|---|---|---|---|
| LHE | AT8 | Aβ42 | TDP43 | BIEL | |
| Superior frontal (BA 8, 9) | X | X | |||
| Dorsolateral superior frontal (BA 45, 46) | X | X | X | ||
| Caudate nucleus, nucleus accumbens, putamen | X | X | |||
| Temporal pole (BA 38) | X | X | |||
| Superior temporal gyrus (BA 20, 21,22) | X | X | X | ||
| Amygdala, with entorhinal cortex (BA 28) | X | X | |||
| Hippocampus and lateral geniculate nucleus | X | X | X | X | X |
| Thalamus and mammillary body | X | X | |||
| Cerebellum with dentate nucleus | X | X | |||
Digitized images of the following microscopic slides were provided to the evaluating neuropathologists on 25 cases of tauopathies including AD, AGD, CBD, CTE, GPDC, PART and PSP. The slides were all uniformly processed by a single laboratory
Aβ Beta-amyloid, AD Alzheimer’s disease, AGD Argyrophilic grain disease, BA Brodmann area, BIEL Bielschowsky’s silver method, CTE Chronic traumatic encephalopathy, GPDC Guamanian Parkinson’s dementia complex, LHE Luxol fast blue, counterstained with hematoxylin and eosin, PART Primary age-related tauopathy, PSP Progressive supranuclear palsy