Table 4.
Enrichment of OFC-associated genes (OFC-AGs) in candidate OFC genes identified by CNV analysis
| Deletions | Duplications | |||
|---|---|---|---|---|
| No. of total genes | No. of OFC-AGsa | No. of total genes | No. of OFC-AGs | |
| All genes without prioritization | 5809 | 49 | 5941 | 30 |
| Prioritized genes | 45 | 11 | 27 | 3 |
| Fold enrichment | 28.98 | 22.00 | ||
| P value (Hypergeometric test) | 7.2 × 10−16 | 8.6 × 10−6 | ||
aOFC-AGs: OFC-associated genes. Genes that have been associated with OFC or orofacial development based on extensive literature search (Supplementary Table 2)