Table 2.
Structural parameters for different hGMPK conformations as derived with SAXS measurements
hGMPK sample | Conformation | I(0) × 10−2 | R g (Å) | D max (Å) |
---|---|---|---|---|
Apo-form | Open | 1.3 | 20.1 (± 0.04) | 50.0 |
GMP + AMP-PNP | Completely closed 1 | 1.4 | 18.4 (± 0.04) | 50.0 |
Ap5G | Completely closed 2 | 1.4 | 18.1 (± 0.03) | 50.0 |
GMP + ADP | Completely closed 3 | 1.4 | 18.4 (± 0.04) | 51.0 |