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. Author manuscript; available in PMC: 2016 Jan 3.
Published in final edited form as: Cancer Lett. 2010 Feb 4;293(1):124–131. doi: 10.1016/j.canlet.2010.01.004

Figure 3. EAD induces Topoisomerase I/II-mediated DNA cleaving activity.

Figure 3

A. The induction of topoisomerase I (Top 1)DNA complexes by EAD was measured using DNA cleavage assays as described in Materials and Methods. Doses of drugs: camptothecin (CPT) at 1 μM; EAD at 1, 10, and 100 μM. B. The induction of topoisomerase II (Top2)-DNA complexes by EAD was measured using DNA cleavage assays as described in Materials and Methods. Doses of drugs: etoposide at 0.1, 1, 10, and 100 μM; EAD at 0.1, 1, 10, and 100 μM.