Table 1.
Comparison of gene expression profiles for common compounds present in NB dataset and cMAP
| Drug | Instances | Higher concentration | Lower concentration | ||||
|---|---|---|---|---|---|---|---|
|
| |||||||
| Rank | Score | p-value | Rank | Score | p-value | ||
| 5-Azacitinide | 3 | 5 | 0.96 | <0.001 | 56 | 0.74 | 0.036 |
| Alsterpaullone | 3 | 1 | 1 | <0.001 | 11 | 0.97 | <0.001 |
| Camptothecin | 3 | 1 | 1 | <0.001 | 2 | 1 | <0.001 |
| Colchicine | 6 | 31 | 0.61 | 0.012 | 47 | 0.56 | 0.027 |
| Daunorubicin | 4 | 389 | 0.38 | 0.508 | 32 | 0.73 | 0.011 |
| Doxorubicin | 3 | 1 | 1 | <0.001 | 952 | -0.46 | 0.430 |
| Etoposide | 4 | 525 | 0.32 | 0.72 | 768 | -0.31 | 0.748 |
| Mitoxantrone | 3 | 1 | 1 | <0.001 | 816 | -0.4 | 0.595 |
| Paclitaxel | 4 | 622 | 0.21 | 0.91 | 444 | -0.27 | 0.860 |
| Tetrandrine | 4 | 39 | 0.68 | 0.023 | 370 | 0.38 | 0.505 |