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. Author manuscript; available in PMC: 2016 Jan 3.
Published in final edited form as: Cancer Lett. 2010 Feb 4;293(1):124–131. doi: 10.1016/j.canlet.2010.01.004

Table 2.

List of compounds showing high connectivity with EAD in cMAP analysis

Rank Drug name Dose Cell Score Instance_id Mechanism of action
1 Phenoxybenzamine 12 μM PC3 1 4652 Alpha blockade/alkylation
2 Irinotecan 100 μM PC3 0.974 7535 Top1 inhibition
3 Phenoxybenzamine 12 μM MCF7 0.918 5248 Alpha blockade
4 Irinotecan 100 μM MCF7 0.898 7530 Top1 inhibition
5 Camptothecin 11 μM PC3 0.86 4541 Top1 inhibition
6 Camptothecin 11 μM MCF7 0.819 3887 Top1 inhibition
7 Phenoxybenzamine 12 μM MCF7 0.808 5613 Alpha blockade
8 Hycanthone 11 μM MCF7 0.74 5691 DNA intercalation
9 Hycanthone 11 μM PC3 0.735 4630 DNA intercalation
10 Daunorubicin 1 μM PC3 0.695 7511 DNA intercalation/Top2 inhibition
11 Trichostatin A 1 μM PC3 0.687 5950 HDAC inhibition
12 Ellipticine 16 μM PC3 0.674 5779 DNA intercalation/Top2 inhibition
14 Trichostatin A 100 nM PC3 0.649 4302 HDAC inhibition
17 Irinotecan 100 μM MCF7 0.624 7498 Top1 inhibition
19 Trichostatin A 100 nM PC3 0.612 5086 HDAC inhibition