Table 3.
List of compounds showing high connectivity with EAD in query against internal NB-cMAP database
| Rank | Drug name | Dose | Score | Mechanism of action |
|---|---|---|---|---|
| 1 | Echinomycin | 5 nM | 1 | DNA Intercalation |
| 2 | Daunorubicin | 1 μM | 0.94 | DNA intercalation/Top2 inhibition |
| 3 | Doxorubicin | 1 μM | 0.91 | DNA intercalation/Top2 inhibition |
| 4 | Mitoxantrone | 1 μM | 0.9 | DNA intercalation/Top2 inhibition |
| 5 | Camptothecin | 1 μM | 0.86 | Top1 inhibition |
| 6 | Echinomycin | 0.5 nM | 0.81 | DNA Intercalation |
| 7 | Teniposide | 10 μM | 0.77 | Top2 inhibition |
| 8 | EAD | 0.5 μM | 0.74 | Unknown |
| 9 | Amonafide | 10 μM | 0.71 | DNA intercalation/Top2 inhibition |
| 10 | Daunorubicin | 10 μM | 0.7 | DNA intercalation/Top2 inhibition |