Table 6.
Supplemental analysis showing additional brain regions where post-training versus pre-training fMRI measurements significantly correlated with changes in the Cogmed Training Index score of WM exercise performance. The analysis used using Monte Carlo simulations to set clusterwise control over false positives across the whole brain at p<.05.
| Brain region | Peak x, y, z | Peak t | Cluster extent |
|---|---|---|---|
| Encoding | |||
|
| |||
| Post-Training Increases | |||
| Right pre/postcentral gyri (sensorimotor cortex) | 54, −16, 34 | 5.43 | 119 |
| Left cerebellum | −15, −52, −32 | 4.57 | 388 |
| Post-Training Decreases | |||
| Medial frontal gyrus (BA 6/9/8) | 0, 38, 40 | 3.98 | 32 |
|
| |||
| Maintenance | |||
|
| |||
| Post-Training Increases | |||
| Right inferior frontal gyrus (BA 45/9) | 63, 17, 22 | 3.63 | 39 |
| Right pre/postcentral gyrus (sensorimotor cortex) | 63, −7, 13 | 3.81 | 79 |
| Left middle/inferior temporal gyri | −51, −37, −17 | 3.97 | 44 |
| Bilateral cuneus (BA 18/19/17) | 0, −88, 13 | 3.49 | 381 |
| Right middle temporal/middle occipital gyri | 45, −79, 10 | 3.82 | 41 |
| Bilateral cerebellum (anterior lobe) | −9, −52, −26 | 5.07 | 567 |
| Post-Training Decreases | |||
| Medial frontal gyrus (BA 6/9/8) | 3, 41, 43 | 3.65 | 34 |
|
| |||
| Retrieval | |||
|
| |||
| Post-Training Increases | |||
| Left inferior frontal gyrus (BA 44/45) | −60, 14, 7 | 2.97 | 32 |
| Left middle temporal/fusiform gyri | −48, −37, −20 | 4.27 | 42 |
| Left middle/inferior occipital gyri (BA 18) | −30, −97, −8 | 3.82 | 70 |
| Cerebellum | 6, −58, −23 | 3.78 | 41 |
| Brainstem (pons/midbrain) | −6, −28, −23 | 3.31 | 63 |
| Post-Training Decreases | |||
| Left superior temporal gyrus/insula | −36, 2, −14 | 3.75 | 32 |