The effect of acute dobutamine treatment on cardiac performance. Data are presented as means ± SE of n = 6 ACTC E361G (open bars) mice and n = 7 NTG (solid bars) mice. Δ, change from the baseline. Heart rate (A), stroke volume (SV; B), cardiac output (CO; C), end-systolic pressure (ESP; D), maximum rate of pressure increase (dP/dtmax; E), end-systolic volume (ESV; F), maximum rate of pressure decline (dP/dtmin; G), tau (H), and end-diastolic volume (EDV; I). **P < 0.01, ***P < 0.001, ****P < 0.0001, unpaired Student's t-test.