Effect of 4 wk ANG II (1.4 mg·kg−1·day−1) infusion on cardiac dimensions of ACTC E361G and NTG mouse hearts measured by M-mode echocardiography. Data are presented as means ± SE of n = 8 ACTC E361G (open circles and lines) and n = 6 NTG (solid circles and lines) mice. Heart rate (A), CO (B), SV (C), ejection fraction (EF; D), end-diastolic left ventricle internal dimension at diastole (LVIDd; E), end-diastolic interventricular septum thickness (IVSd; F), ESV (G), and EDV (H). Data were analyzed by 2-way ANOVA (+P < 0.05, ++P < 0.01, +++P < 0.001 ACTC E361G vs. baseline; #P < 0.05, ##P < 0.01 NTG vs. baseline; *P < 0.05 ACTC E361G vs. NTG).