Fig. 1.

Cardiomyocyte-specific Bmal1 knockout (CBK) mice promoted age-onset dilative hypertrophy and diastolic dysfunction. A: images of wheat germ agglutinin (WGA) at 8 and 28 wk representing increase in cardiomyocyte size indicating age-associated hypertrophy at 28 wk in CBK mice (scale bars: 10 μm). B: quantitation of cardiomyocyte area/section per mouse indicated hypertrophic response at 28 wk of age in CBK mice. *P < 0.05 vs. age-matched control (CON); n = 5 mice/group. C: representative echocardiographic images with abnormal diastolic septal annular wall motion indicating diastolic dysfunction in CBK mice at 28 wk compared with age-matched controls.