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Aging-prone CBK mice showed accelerated extracellular matrix remodeling. A: immunoblot representing increase in expression of MMP-9, TIMP-1, and collagen I and III in LV of CBK mice compared with littermate controls at 28 wk of age. Densitometric analyses of MMP-9 (B), TIMP-1 (C), and collagen I (D) and III (E); β-actin was used as loading control. *P < 0.05 vs. age-matched control; n = 5 mice/group.
