Table 1.

Necropsy parameters at 8 wk and 28 wk in control and CBK mice

Groups:	Control		CBK
Age/Sample Size:	8 wk (n = 6)	28 wk (n = 12)	8 wk (n = 5)	28 wk (n = 10)
Body weight, g	26 ± 1	32 ± 1	25.8 ± 0.8	28.9 ± 0.9*
Tibia, mm	17 ± 0.1	18 ± 0.1	17 ± 0.1	18 ± 0.2
Spleen, mg	73 ± 7	90 ± 13	75 ± 8.6	67 ± 3
RV, mg	18 ± 1	24 ± 1	22 ± 1	26 ± 2
LV, mg	83 ± 2	97 ± 3	96 ± 3*	109 ± 8
RV/BW	0.70 ± 0.03	0.77 ± 0.04	0.86 ± 0.04	0.91 ± 0.07
LV/BW	3.1 ± 0.07	3.0 ± 0.09	3.7 ± 0.05	3.82 ± 0.31*
Lung wet weight, mg	155 ± 13	167 ± 12	144 ± 7	180 ± 9
Lung dry weight, mg	29 ± 2	35 ± 2	31 ± 2	37 ± 3
LV/tibia	4.8 ± 0.1	5.6 ± 0.2	5.4 ± 0.2	6.1 ± 0.4

Values are means ± SE.

RV, right ventricle; LV, left ventricle; BW, body weight; Control, littermate; CBK, cardiomyocyte-specific Bmal-1 deleted knockout.

^*P < 0.05 vs. wild type.