Table 1.
IPA analysis identified significant functional categories modulated by iron irradiation
| Time | Functional Category (Function) | P Value | Predicted Activation | Activation z-Score |
|---|---|---|---|---|
| Day 1 | Inflammatory response (arthritis, rheumatic disease & inflammation) | 2.86E-08 | Decreased | −2.52 |
| cellular growth and proliferation (proliferation) | 2.50E-03 | Increased | 2.07 | |
| Day 3 | Cardiovascular disease (vascular disease) | 7.14E-07 | Decreased | −2.33 |
| Cellular development (differentiation) | 1.39E-07 | Decreased | −2.27 | |
| Free-radical scavenging (synthesis & production) | 4.90E-05 | Decreased | −2.70 | |
| Inflammatory response (arthritis, rheumatic disease & inflammation) | 1.67E-06 | Decreased | −2.15 | |
| Day 7 | Infectious disease (infection) | 1.75E-11 | Decreased | −2.72 |
| Cell death and survival (cell death, necrosis & apoptosis) | 5.18E-04 | Increased | 2.00 | |
| Cell-to-cell signaling and interaction (binding) | 8.08E-05 | Increased | 2.74 | |
| Free-radical scavenging (production) | 6.98E-04 | Increased | 2.002 | |
| Hematological system development and function, cellular development & tissue morphology (differentiation & quantity) | 9.27E-06 | Increased | 2.07 | |
| Inflammatory response (arthritis, rheumatic disease, inflammation & immune response) | 3.20E-05 | Increased | 2.10 | |
| Molecular transport (quantity) | 1.10E-03 | Increased | 2.28 | |
| Day 14 | Cell death and survival (apoptosis) | 9.04E-05 | Decreased | −2.21 |
| Cell-to-cell signaling and interaction (activation) | 1.50E-02 | Decreased | −2.59 | |
| Inflammatory response (immune response) | 3.09E-04 | Decreased | −2.39 | |
| Tissue development & cellular assembly and organization (formation & fibrogenesis) | 1.25E-03 | Decreased | −2.01 | |
| Day 28 | Inflammatory response (activation) | 2.18E-03 | Decreased | −2.41 |
| Hematological system development and function & tissue morphology (quantity) | 2.24E-03 | Decreased | −2.00 | |
| Cell death and survival (apoptosis) | 1.05E-02 | Decreased | −2.00 | |
| Cell death and survival (survival) | 1.76E-03 | Increased | 2.08 | |
| Cardiovascular system development and function | 8.27E-05 | Increased | 2.13 | |
| Embryonic, organismal, and organ development, & tissue development (development) | 3.02E-03 | Increased | 2.32 | |
| Free-radical scavenging (production) | 8.41E-03 | Increased | 2.15 | |
| Hematological system development and function, humoral immune response & tissue morphology (quantity) | 1.19E-04 | Increased | 2.33 |
Functional categories were examined by day and considered significant with a z-score > 2.0, activated, or below less than −2.0, inhibited. Right-tailed Fisher's exact test was used to calculate a P value determining the probability that each biological function and/or disease assigned to that data set is due to chance alone.