Table 3.
Predicted upstream cytokine and transcriptional regulators based on dataset overlap with Ingenuity Pathway Analysis database
| z-Score (No. of Target Genes) |
||||||
|---|---|---|---|---|---|---|
| Type | Upstream Regulator | Day 1 | Day 3 | Day 7 | Day 14 | Day 28 |
| Transcriptional regulator | MYCN | +2.22 (5) | ||||
| Transcriptional regulator | TP53 | −2.05 (44) | ||||
| Transcriptional regulator | MYC | +2.85 (20) | +2.69 (22) | |||
| Transcriptional regulator | HTT | −2.00 (17) | −2.00 (21) | |||
| Transcriptional regulator | NFKBIA | −2.47 (13) | −3.21 (16) | −2.81 (8) | ||
| Cytokine | IL10 | −2.36 (12) | −2.65 (16) | +2.59 (14) | ||
| Transcriptional regulator | CEBPA | +2.57 (12) | ||||
| Cytokine | IFNG | +4.14 (48) | ||||
| Cytokine | IL1B | +3.28 (32) | ||||
| Transcriptional regulator | NOTCH1 | +2.17 (6) | ||||
| Transcriptional regulator | SFPI1 | +3.09 (12) | ||||
| Cytokine | TNF | +3.26 (52) | ||||
| Transcriptional regulator | STAT3 | +2.06 (16) | ||||
| Transcriptional regulator | STAT6 | −2.21 (14) | ||||
| Transcriptional regulator | GATA4 | +2.78 (4) | ||||
| Transcriptional regulator | MEF2C | +2.76 (4) | ||||
| Transcriptional regulator | TBX5 | +2.80 (4) | ||||
| Transcriptional regulator | ARNTL | −2.51 (4) | −2.15 (5) | |||
| Cytokine | IL6 | −2.19 (13) | ||||
A significant P value <0.05 and z-score (more than +2.0, activated, or less than −2.0, inhibited) were chosen.