Table 4.
Major biological and disease-related pathways associated with iron exposures
| KEGG Pathway | Genes, No. | P Value | Genes | Benjamini and Hochberg | FDR, % |
|---|---|---|---|---|---|
| Parkinson's disease | 28 | 4.576E-13 | NDUFB7, ATP5B, COX7B, UBE2G2, CYC1, COX7C, NDUFS6,CASP9, NDUFS1, ATP5J, ATP6, ND1, COX7A1, ND2, ND3, NDUFA1, PARK7, COX6C, VDAC1, SDHA, ND4L, COX3, UQCRH,COX2, COX1, NDUFV2, COX6A2, ATP5C1 | 6.544E-11 | 5.420E-10 |
| Alzheimer's disease | 28 | 1.486E-10 | NDUFB7, ATP5B, COX7B, CYC1, COX7C, NDUFS6, CASP9, PPP3CB, GAPDH, NDUFS1, ATP5J, ATP6, LPL, COX7A1, NDUFA1, NAE1, COX6C, SDHA, ATP2A2, PSEN1,COX3, UQCRH, COX2, COX1, NDUFV2, ATP2A1, COX6A2, ATP5C1 | 1.062E-08 | 1.760E-07 |
| Oxidative phosphorylation | 25 | 2.214E-10 | NDUFB7, ATP5B, COX7B, CYC1, COX7C, ATP6V0B, NDUFS6, NDUFS1, ATP5J, ATP6, ND1, COX7A1, ND2, ND3, NDUFA1, COX6C, SDHA, ND4L, COX3, UQCRH,COX2, COX1, NDUFV2, ATP5C1, COX6A2 | 1.055E-08 | 2.622E-07 |
| Cardiac muscle contraction | 18 | 1.600E-08 | ACTC1, CACNA2D1, COX7A1, MYL2, MYL3, COX7B, CYC1, COX7C, MYH6, CACNB4, COX6C, COX3, ATP2A2, COX2, UQCRH,COX1, COX6A2, ATP6 | 5.720E-07 | 1.895E-05 |
| Huntington's disease | 24 | 5.967E-07 | POLR2E, COX7A1, NDUFB7, ATP5B, COX7B, CYC1, COX7C, NDUFA1, DCTN1, COX6C, VDAC1, SDHA, NDUFS6, COX3, CASP9,COX2, UQCRH, COX1, NDUFV2, COX6A2, ATP5C1, NDUFS1, ATP6, ATP5J | 1.707E-05 | 7.067E-04 |
| HCM | 9 | 0.013 | ACTC1, CACNA2D1, ATP2A2, MYL2, MYL3, ITGB5, MYH6, CACNB4, PRKAA2 | 0.269 | 14.438 |
| Dilated cardiomyopathy | 9 | 0.020 | ACTC1, CACNA2D1, ATP2A2, MYL2, MYL3, PLN, ITGB5, MYH6, CACNB4 | 0.343 | 21.585 |
| Wnt signaling pathway | 12 | 0.024 | PSEN1, PPP2R5B, PPP2R5C, CAMK2D, SMAD4, PPP3CB, FRAT1, FZD1, CXXC4, FBXW11, RBX1, AXIN1 | 0.354 | 25.128 |
| Glycerolipid metabolism | 6 | 0.025 | GLYCTK, LPL, DGKB, PPAP2A, ALDH3A2, AGPAT2 | 0.327 | 25.579 |
| Ubiquitin mediated proteolysis | 11 | 0.030 | RFWD2, CUL3, UBE2D3, UBE2Z, UBE3B, UBE3A, WWP1, UBE2G2, ANAPC11, FBXW11, RBX1 | 0.358 | 30.691 |
| Fatty acid elongation in mitochondria | 3 | 0.033 | PPT2, HADHA, HADHB | 0.355 | 32.954 |
| Glycerophospholipid metabolism | 7 | 0.040 | PGS1, DGKB, PLA2G12B, LYPLA2, PPAP2A, AGPAT2, PTDSS2 | 0.382 | 38.015 |
HCM, hypertrophic cardiomyopathy.
Genes listed were among the top 200 most differentially expressed genes [false discovery rate (FDR) <0.05] between all noncontrol iron microarrays and all noncontrol proton microarrays. P values are Benjamini and Hochberg (Ref. 5) P values. Genes with overrepresentation FDR < 0.05 are listed in bold.