High-fat diet (HFD) increases maternal body weight (A) and reduces placental volume blood flow (B), which is accompanied by increased plasma leptin (C) and insulin (D) levels in the third trimester of pregnancy in baboons. Control, control diet; R, HFD resistant; S, HFD sensitive; cQutv, placental volume blood flow. *P < 0.05 vs. control and HFD R. From Frias AE et al. (52).