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Left: maximum rate of systolic pressure increase (dP/dtmax) was significantly reduced after administration of the β-adrenergic blocking (BB) agent metoprolol. Subsequent addition of atropine (AT) was associated with a further small but significant reduction. Right: systolic blood pressure (SBP) showed no significant change following metoprolol but a significant reduction following the addition of atropine. Error bars indicate SE. C, control. *P < 0.05; **P < 0.01.
