Table 1.
Changes in the arterial blood gases and ventilator mean airway pressure and fractions of inspired oxygen concentrations in PPHN fetal lambs ventilated with oxygen alone or oxygen plus iNO
| Time, h |
|||||
|---|---|---|---|---|---|
| Variables/Group | 0 | 6 | 12 | 18 | 24 |
| MAP, cmH2O | |||||
| iNO | 13 (0.5) | 14 (0.5) | 11* (1.3) | 11* (1.1) | 11* (1.2) |
| Ventilation | 14 (1.5) | 15 (3.2) | 16 (2.0) | 15 (2.6) | 17 (1.5) |
| FiO2 | |||||
| iNO | 100 (0) | 90 (0) | 65* (0.28) | 59* (0.35) | 53* (0.38) |
| Ventilation | 100 (0) | 100 (0) | 100 (0) | 100 (0) | 100 (0) |
| PaO2 | |||||
| iNO | 23.7 (3.78) | 35.6 (25.1) | 104.6* (70.9) | 105.1* (39.2) | 78.9* (5.7) |
| Ventilation | 31.7 (5.3) | 33.2 (17.8) | 29.6 (18.5) | 27.2 (20.5) | 40.8 (3.74) |
| pH | |||||
| iNO | 7.43* (0.02) | 7.33 (0.05) | 7.36* (0.05) | 7.35 (0.01) | 7.36* (0.07) |
| Ventilation | 7.20 (0.01) | 7.31 (0.07) | 7.17 (0.06) | 7.22 (0.11) | 7.12 (0.06) |
| Pco2 | |||||
| iNO | 56 (5.40) | 46.1* (3.40) | 41.1* (0.35) | 41.8* (16.20) | 39.4* (0.92) |
| Ventilation | 45 (2.30) | 38 (0.56) | 56 (6.20) | 80 (49.70) | 69 (3.74) |
iNO, inhaled nitric oxide; AMP, mean arterial pressure; FiO2, fraction of inspired oxygen concentration; PPHN, persistent pulmonary hypertension of the newborn. Numbers in parentheses are standard deviations. *P < 0.05 from ventilated fetal lambs with PPHN with 100% O2 alone.