Fig. 8.

Vascular reactivity to insulin alone (left) and to insulin in the presence of the nonselective endothelin-1 receptor antagonist tezosentan (right) for red gastrocnemius 2A arterioles (G2A-Red and RG2a) (top) and white gastrocnemius 2A arterioles (WG2a) (bottom) across all doses of insulin in 32-wk-old Sed, EndEx, and IST OLETF rats. Values are expressed as mean percent possible dilation ± SE. Within each group and vessel, n = 9–12. δEndEx vs. IST (P < 0.0167). [Published with permission (81).]