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. 2015 Oct 7;310(1):C27–C40. doi: 10.1152/ajpcell.00173.2015

Fig. 6.

Fig. 6.

Switching of MHC isoforms in mouse soleus muscle after unloading and during reloading. A: glycerol SDS-PAGE revealed changes in MHC isoform expression in soleus muscle after 4 wk of unloading and recoveries during early (3–15 days) and later (30–60 days) phases of reloading. B: densitometry quantification determined that 4 wk of unloading of soleus muscle decreased MHC IIa and increased MHC IIx and IIb, whereas no change was seen in MHC I. MHC IIx and IIb returned to control level after 15 days of reloading; MHC IIa started recovering after 7 days of reloading but stayed below normal level at 15–60 days of reloading. Although not affected by unloading, MHC I showed an increase after 30 days of reloading and reached a level higher than normal at 45 and 60 days. Values are presented as means ± SE; n = 4 in CON, n = 5 in HU, n = 4 in 3DR, n = 3 in 7DR, n = 3 in 15DR, n = 8 in 30DR, n = 8 in 45DR, and n = 6 in 60DR. *P < 0.05 vs. CON. Statistics was performed using 1-way ANOVA with mean comparison in Tukey's test.