Table 1.
miRNA | Expression profile | ESCC | EAC | Related biological function | Ref. |
miRNA-21 | ↑ | PTEN | Cell proliferation | [8,17,18] | |
PDCD4 | Cell migration, apoptosis | [9] | |||
Let-7 | ↓ | HMGA2 | Cell proliferation | [25,26] | |
IL-6 | Cytokine activity | [27] | |||
miRNA-143 and -145 | ↓ | FSCN | FSCN | Cell migration | [29,32] |
ERK5 | Cell proliferation, cell migration | [30] | |||
miRNA-196a | ↑ | Annexin A1 | Apoptosis | [38,39] | |
SPRR2C | Pseudogene | [38] | |||
S100A9 | Cell differentiation, cell proliferation | [38] | |||
KRT5 | Cell architecture | [38] | |||
RAP1A | Cell proliferation, cell adhesion and cell migration | [41] |
miRNAs with corresponding expression profile (↑ = upregulated, ↓ = downregulated in esophageal cancer), described targets and related biological function in esophageal squamous cells carcinoma (ESCC) and esophageal adenocarcinoma (EAC).