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Dosage levels of sorafenib and low-dose FP administered to patients with advanced HCC and DLT
| Cohort | Sorafenib (mg/day) | CDDP (mg/m2, day 1, 8) | 5-FU (mg/m2/day, Days 1–5, Days 8–12) | DLT | Remarks | |
|---|---|---|---|---|---|---|
| 0 | 800 | 10 | 170 | |||
| 1 | 800 | 14 | 170 | DLT 2/6 | EM in 1 case PLT and EM in 1 case | Starting dose |
| 2 | 800 | 14 | 330 | DLT 1/6 (EM) | EM in 1 case | |
| 3 | 800 | 20 | 330 | DLT 0/6 | Recommended dose |
EM=Erythema multiforme; PLT=thrombocytopenia; FP=CDDP+5-FU.
