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. 2016 Jan 4;6:18696. doi: 10.1038/srep18696

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Copyright © 2016, Macmillan Publishers Limited

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(A) At the beginning of VAS expansion, the nucleus is still large and few budding vesicles are observed. Some of the mitochondria surrounding the VAS have lost their inner cristae, and may become the vacant vesicle for viral particles to bud into. (B) As more vesicles develop and take up space inside the cell, the nucleus reduces in size and is pushed towards the edge of the cell. (C) Vesicles fuse with each other to form large vacuoles and eventually create an opening in the cell membrane enabling the release of viral particles. At this stage, the nucleus has dramatically reduced in size and remains at the cell periphery. These images were obtained from SGIV infected GECs at 8 hpi, scale bar = 1 μm.