Figure 7. Schematic of the SGIV life cycle.

SGIV enters the cell through endocytosis and this leads to the formation of coated vesicles containing virions. These vesicles are transported to the nucleus and release the viral genome into the nucleus. Viral replication results in the formation of the viral assembly site in the cytoplasm, the location for viral morphogenesis. The steps involved in viral morphogenesis and capsid assembly are shown in the inset. Mature virions either accumulate inside the cytoplasm as paracrystalline arrays and are released through host cell lysis, and can also be released by budding, either directly through the cell membrane, or by the formation of budding vacuoles within the cell.