Figure 1. Overview of approach and metabolism alterations in cancer cells.

(A) Schematic showing the approach and datasets used in the study to identify metabolic alterations that are relevant to metastatic progression of cancer cells. Mutation, CNA and mRNA expression data of the genes in the literature-derived model were analyzed for statistical significance in samples stratified by metastatic status. (B) Literature-derived metabolic pathway model showing the genetic alterations that control glucose and fatty acid metabolism in cancer cells. The genes affecting FA transport were included in the pathway as potential contributors to the FA pool. FATPs indicate FATP1-6, FABPs indicate FABP1-9, and PPARs indicate PPAR-α, -δ and -γ. Silver ovals = proteins/enzymes, gold ovals = transcription factors, blue box = metabolites, dashed lines = transport, yellow box = ATP.