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. 2016 Jan 4;6:18669. doi: 10.1038/srep18669

Figure 5. Association between metabolic gene expression and metastatic potential in multiple cancers.

Figure 5

Heatmaps showing expression profiles of EMT and metabolic genes in (A) Breast invasive carcinoma, BRCA (n = 1037) (B) Colorectal adenocarcinoma, COADREAD (n = 352) (C) KIRC (n = 518) (D) Liver hepatocellular carcinoma LIHC (n = 191) (E) LUAD (n = 230) (F) Ovarian serous cystadenocarcinoma, OV (n = 261) (G) Prostate adenocarcinoma, PRAD (n = 236). The tumor samples (X-axis) are ordered according to EMT score shown in bottom row of each heatmap and genes (Y-axis) are arranged in hierarchical clusters (average linkage method, Pearson’s correlation distance metric). Genes with significant positive (+) or negative (−) correlation with EMT score are listed next to the heatmap, along with a schematic of the metabolic processes predicted to be altered on the basis of significant correlation in each cancer type. (H) Circos diagram showing the relationship between the percentage of significant EMT-associated genes within each cancer type and the percent contribution to the total number of significant EMT-associated genes within each model category.