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. 2016 Jan 4;6:18669. doi: 10.1038/srep18669

Figure 6. Influence of fatty acid metabolism gene signature on patient survival.

Figure 6

(A) Odds ratio obtained from logistic regression analysis demonstrating association between individual metabolism genes and EMT (low or high) across the seven cancer types, with shades of grey indicating increasing odds ratio. (B) Bar graphs showing cumulative rank sum of odds-ratio –log10 p-value of individual genes across all seven cancer types. T1-5 and B1-5 indicate the five top and bottom ranked genes respectively (C,D). Kaplan-Meier survival curve for pan-cancer tumors stratified by two mRNA expression clusters. The sample clusters were obtained by K-means (k = 2) using (C) top 5 genes (CPT1C, CAV1, CD36, MLXIPL, CYP2E1) or (D) bottom 5 genes (PFKFB3, PPARG, FABP7, CYP4A22, SLC27A6) from the rank-sum analysis. P-value indicates significance levels from the comparison of survival curves using the Log-rank (Mantel-Cox) test. (E,F) Kaplan-Meier survival curves for (E) head & neck cancer (HNSC) or (F) melanoma (SKCM) tumors stratified by the mRNA expression profiles of the top-ranked genes identified in the previous analysis.