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. 2015 Sep 21;29(1):36–42. doi: 10.5713/ajas.15.0476

Table 1.

F1 generation’s (the next in the current generation) allele frequency change according to the single nucleotide polymorphism (SNP) effect under linear additive model1

Allele frequency (P) 0.25 (AA) 0.5 (AA′) 0.25 (A′A′)
Fitness change 1-2u 1-u 1
SNP effect Allele frequency change(F1)
0.5 0 0.5 0.5
0.05 0.24 0.5 0.26
0.25 0.17 0.5 0.33
0.005 Approximately HWE Approximately HWE Approximately HWE
0 HWE HWE HWE
1

We assumed the Hardy-Weinberg equilibrium (HWE) in P (Parental) generation and depicted the SNP effect as selection coefficient according to Equation (4). The allele coded as “2” assumed to be A′A′ and u denoted SNP effect*.

*Note that the SNP effect is sensitive to the unit of phenotypic values and we assumed that the SNP effect would be the selection coefficient*2