Table 1.
F1 generation’s (the next in the current generation) allele frequency change according to the single nucleotide polymorphism (SNP) effect under linear additive model1
Allele frequency (P) | 0.25 (AA) | 0.5 (AA′) | 0.25 (A′A′) |
---|---|---|---|
Fitness change | 1-2u | 1-u | 1 |
SNP effect | Allele frequency change(F1) | ||
0.5 | 0 | 0.5 | 0.5 |
0.05 | 0.24 | 0.5 | 0.26 |
0.25 | 0.17 | 0.5 | 0.33 |
0.005 | Approximately HWE | Approximately HWE | Approximately HWE |
0 | HWE | HWE | HWE |
We assumed the Hardy-Weinberg equilibrium (HWE) in P (Parental) generation and depicted the SNP effect as selection coefficient according to Equation (4). The allele coded as “2” assumed to be A′A′ and u denoted SNP effect*.
*Note that the SNP effect is sensitive to the unit of phenotypic values and we assumed that the SNP effect would be the selection coefficient*2