Table 2. Summary risk estimates of the association between ever parity and gastric cancer risk.
No. of Study | SRR | 95% CI | I2 (%) | Ph† | Ph‡ | |
---|---|---|---|---|---|---|
Overall | 7 | 0.96 | 0.87–1.05 | 0 | 0.504 | |
Subgroup analyses | ||||||
Number of cases | 0.383 | |||||
≥250 | 3 | 0.96 | 0.85–1.08 | 15.1 | 0.317 | |
<250 | 4 | 0.84 | 0.62–1.13 | 0 | 0.594 | |
Follow-up years | 0.974 | |||||
≥10 | 2 | 0.90 | 0.87–1.05 | 42.4 | 0.176 | |
<10 | 5 | 0.94 | 0.81–1.11 | 0 | 0.593 | |
Geographic location | 0.221 | |||||
Europe | 3 | 0.98 | 0.89–1.08 | 0.8 | 0.388 | |
Asia | 3 | 0.80 | 0.58–1.12 | 0 | 0.517 | |
North America | 1 | 0.76 | 0.44–1.31 | N/A | N/A | |
Menopausal status | 0.962 | |||||
Pre-menopausal | 1 | 0.83 | 0.65–1.05 | N/A | N/A | |
Post-menopausal | 3 | 0.83 | 0.61–1.13 | 66.7 | 0.029 | |
Anatomic subsite | 0.279 | |||||
Cardia | 2 | 0.81 | 0.61–1.07 | 1.2 | 0.314 | |
Non-cardia | 3 | 0.99 | 0.88–1.12 | 0 | 0.589 | |
Adjustment for potential confounders and risk factors | ||||||
Age | 0.769 | |||||
Yes | 5 | 0.95 | 0.82–1.10 | 0 | 0.862 | |
No | 2 | 0.82 | 0.59–1.15 | 60.0 | 0.082 | |
Cigarette smoking | 0.974 | |||||
Yes | 5 | 0.95 | 0.81–1.11 | 0 | 0.593 | |
No | 2 | 0.90 | 0.72–1.12 | 42.4 | 0.176 | |
Body mass index | 0.617 | |||||
Yes | 4 | 0.97 | 0.82–1.14 | 0 | 0.827 | |
No | 3 | 0.85 | 0.68–1.08 | 44.3 | 0.146 | |
Alcohol drinking | 0.844 | |||||
Yes | 3 | 0.88 | 0.67–1.15 | 24.6 | 0.265 | |
No | 4 | 0.97 | 0.86–1.08 | 0 | 0.468 | |
Socioeconomic status | 0.340 | |||||
Yes | 5 | 0.97 | 0.87–1.07 | 3 | 0.397 | |
No | 2 | 0.81 | 0.58–1.12 | 0 | 0.774 |
CI, confidence interval; N/A, not available; SRR, summarized relative risk.
†P-value for heterogeneity within each subgroup.
‡P-value for heterogeneity between subgroups with meta-regression analysis.