Figure 2. Manhattan and regional plots for pleiotropic ABO variant associations with plasma levels of ACE, SELE, and vWF.

(a) Manhattan plot of −log₁₀ p-values for association with plasma levels of ACE; (b) Regional plot for genome-wide significant associations in ABO locus with ACE plasma levels; (c) Manhattan plot of −log₁₀ p-values for association with plasma levels of SELE; (d) Regional plot for genome-wide significant associations in ABO locus with SELE plasma levels; (e) Manhattan plot of -log₁₀ p-values for association with plasma levels of vWF; (f) Regional plot for associations in ABO locus with vWF plasma levels, rs687289 was close to genome-wide significance (p = 8.87 × 10⁻⁸).