Table 1.

Tissue optical properties and photosensitizer concentrations before HPPH-mediated PDT as well as the treatment conditions. Each group contains four mice bearing RIF tumors: three for the treatment and one mouse as a control. The measured values are presented with their standard deviations.

PDT conditions					Optical properties		Post-PDT
LSa ($\mathrm{mW}/\mathrm{cm}$)	Timeb (s)	HPPH ($\mu \mathrm{M}$)	Energyc ($\mathrm{J}/\mathrm{cm}$)	PDT dosed ($\mu \mathrm{M}\mathrm{J}/{\mathrm{cm}}^2$)	${\mu }_{\mathrm{a}}({\mathrm{cm}}^{-1})$	${\mu }_{\mathrm{s}}^{\prime }$ (${\mathrm{cm}}^{-1}$)	Tumor SFe	Necrosis radiusf (mm)	Control radius (mm)	PDT-induced necrosisg (mm)
12	1000	$0.38\pm 0.03$	12	3.62	$0.85\pm 0.03$	$8.9\pm 0.7$	$1.24\pm 0.09$	$2.3\pm 0.6$	2.3	$0.06\pm 0.5$
12	3600	$0.40\pm 0.03$	43	11.47	$0.7\pm 0.1$	$9.1\pm 0.5$	$1.21\pm 0.09$	$3.0\pm 0.7$	2.5	$0.8\pm 0.6$
30	660	$0.6\pm 0.3$	20	9.81	$0.74\pm 0.08$	$8.9\pm 0.2$	$1.3\pm 0.2$	$2.7\pm 0.5$	2.4	$0.5\pm 0.5$
75	1000	$0.35\pm 0.04$	75	14.41	$0.79\pm 0.01$	$8.8\pm 0.1$	$1.3\pm 0.2$	$3.3\pm 0.5$	1.8	$1.1\pm 0.5$
30	1000	$0.5\pm 0.3$	30	11.79	$0.65\pm 0.05$	$9.6\pm 0.6$	$1.15\pm 0.03$	$3.0\pm 0.2$	2.4	$0.8\pm 0.3$
30	500	$1.20\pm 0.02$	15	18.52	$0.6\pm 0.1$	$9.6\pm 0.6$	$1.2\pm 0.1$	$2.8\pm 0.4$	2.0	$0.6\pm 0.4$
75	400	$0.7\pm 0.1$	30	19.19	$0.7\pm 0.1$	$8.0\pm 0.6$	$1.2\pm 0.2$	$2.7\pm 0.4$	2.2	$0.5\pm 0.4$
75	666	$0.41\pm 0.05$	50	12.07	$1.0\pm 0.2$	$10.1\pm 0.4$	$1.2\pm 0.2$	$3.0\pm 0.4$	2.3	$0.8\pm 0.4$
150	666	$0.46\pm 0.08$	100	26.90	$0.83\pm 0.05$	$11\pm 2$	$1.13\pm 0.02$	$4.4\pm 0.5$	2.3	$2.2\pm 0.5$

^aLight source strength.

^bLight exposure time.

^cTotal delivered energy per length.

^dPDT dose was calculated from the time integration of the HPPH concentration and light fluence rate.

^eTumor shrinkage factor.

^fMeasured necrotic radius without subtracting the control radius.

^gMeasured necrotic radius with subtracting the mean control necrotic radius. The mean necrotic radius (the spontaneous necrosis and the necrosis induced by light and/or catheter insertion) was $2.2\pm 0.2\mathrm{mm}$, obtained from nine controls belonging to the nine groups of the mice.