Table 5.
| Manifestation | Treatment |
|---|---|
| Mucocutaneous | |
| Mild | Topical steroids |
| Moderate to severe | Initial: |
| Systemic steroid | |
| Colchicine | |
| Refractory case: | |
| Azathioprine | |
| Interferon α | |
| Eye | Initial: |
| Systemic steroid + azathioprine | |
| Refractory case: | |
| (1st) Cyclosporine A + steroid + azathioprine | |
| (2nd) Interferon α +/− systemic steroid | |
| Arthritis | (1st) Colchicine |
| Nonsteroidal anti-inflammatory drug | |
| (2nd) Azathioprine | |
| Interferon α | |
| Vessels | |
| Deep venous thrombosis | Azathioprine |
| Cyclosporine A | |
| Cyclophosphamide (larger vessels) | |
| Arterial aneurysm | Cyclophosphamide + systemic steroid |
| Neurological | Cyclophosphamide (drug of choice) |
| Cyclosporine A (contraindicated) | |
| Gastrointestinal | Systemic steroid |
| Sulfasalazine | |
| Azathioprine |