Table 4.
Transcripts involved in IL17, IL6, and IL10 signaling based on IPA canonical pathways annotation. IL17 signaling pathways were the most significantly enriched pathways in response to asbestos exposure in all four cell lines. IL6 and IL10 signaling pathways were also highly enriched and included many of the same transcripts. Bolded transcripts are in all three signaling pathways.
| RefSeq ID | Gene symbol | RefSeq ID | Gene symbol |
|---|---|---|---|
| NM_182810 | ATF4 (IL17) | NM_001165412 | NFKB1 |
| NM_001675 | ATF4 (IL17) | NM_003998 | NFKB1 |
| NM_002982 | CCL2 (IL17) | NM_002502 | NFKB2 |
| NM_001130046 | CCL20 (IL17) | NM_001261403 | NFKB2 |
| NM_004591 | CCL20 (IL17) | NM_001077494 | NFKB2 |
| NM_001040021 | CD14 (IL6 and IL10) | NR_048560 | NFKB2 |
| NM_001174104 | CD14 (IL6 and IL10) | NM_020529 | NFKBIA |
| NM_001174105 | CD14 (IL6 and IL10) | NM_004556 | NFKBIE |
| NM_000591 | CD14 (IL6 and IL10) | NM_005026 | PIK3CD (IL17 and IL6) |
| NM_000758 | CSF2 (IL17) | NM_000963 | PTGS2 (IL17) |
| NM_001511 | CXCL1 (IL17) | NM_001243984 | RELA |
| NR_046035 | CXCL1 (IL17) | NM_021975 | RELA |
| NM_002089 | CXCL2 (IL17) | NM_001145138 | RELA |
| NM_002090 | CXCL3 (IL17) | NM_001243985 | RELA |
| NM_002994 | CXCL5 (IL17) | NM_003955 | SOCS3 (IL6 and IL10) |
| NM_002993 | CXCL6 (IL17) | NM_000594.5 | TNF (IL6 and IL10) |
| NM_005252 | FOS | NM_007115 | TNFAIP6 (IL6) |
| NM_002133 | HMOX1 (IL10) | NM_002546 | TNFRSF11B (IL6) |
| NM_000575 | IL1A (IL6 and IL10) | NM_001171622 | VEGFA (IL6) |
| NM_000576 | IL1B | NM_001171630 | VEGFA (IL6) |
| NM_003856 | IL1RL1 (IL6 and IL10) | NM_001025369 | VEGFA (IL6) |
| NM_033439 | IL33 (IL6 and IL10) | NM_001171627 | VEGFA (IL6) |
| NM_001199640 | IL33 (IL6 and IL10) | NM_001204384 | VEGFA (IL6) |
| NM_001199641 | IL33 (IL6 and IL10) | NM_001204385 | VEGFA (IL6) |
| NM_000418 | IL4R (IL10) | NM_001025370 | VEGFA (IL6) |
| NM_001257406 | IL4R (IL10) | NM_001171628 | VEGFA (IL6) |
| NM_001257997 | IL4R (IL10) | NM_001033756 | VEGFA (IL6) |
| NM_001257407 | IL4R (IL10) | NM_001171629 | VEGFA (IL6) |
| NM_000600 | IL6 | NM_001025368 | VEGFA (IL6) |
| NM_000584 | IL8 (IL17 and IL6) | NM_001171626 | VEGFA (IL6) |
| NM_002228 | JUN (IL6 and IL10) | NM_001025367 | VEGFA (IL6) |
| NM_139046 | MAPK8 | NM_001171625 | VEGFA (IL6) |
| NM_139047 | MAPK8 | NM_001171624 | VEGFA (IL6) |
| NM_004759 | MAPKAPK2 (IL6) | NM_003376 | VEGFA (IL6) |
| NM_032960 | MAPKAPK2 (IL6) | NM_001025366 | VEGFA (IL6) |
| NM_001197320 | MCL1 (IL6) | ||
| NM_021960 | MCL1 (IL6) | ||
| NM_182763 | MCL1 (IL6) |