Table 1.

Type I error simulation results for quantitative traits. Each cell in the table corresponds to the type I error of SKAT using a kernel constructed based on the testing procedure at the top of the table and the grouping strategy at the left of the table. Rows and columns labeled MK-SKAT correspond to the omnibus tests across tests (with fixed group) and across groupings (with fixed test). The cells with both rows and columns labeled MK-SKAT correspond to the omnibus test across all test and groupings

	C-alpha	SKAT	CAST	Count	MK-SKAT
n=1000
0.5%	0.048	0.047	0.050	0.049	0.048
1%	0.048	0.049	0.049	0.050	0.050
3%	0.048	0.049	0.051	0.051	0.051
MK-SKAT	0.050	0.051	0.051	0.051	0.051
n=2000
0.5%	0.049	0.049	0.050	0.050	0.052
1%	0.047	0.047	0.050	0.050	0.051
3%	0.047	0.047	0.050	0.049	0.051
MK-SKAT	0.052	0.051	0.052	0.051	0.050