Figure 1.

Treatment and MRI evaluation timeline. Patients were treated with 60 Gy of external beam radiation therapy (2-Gy fractions given once daily for 5 days over a 6-week period) with concomitant TMZ (75 mg/m² orally or intravenously for 42 consecutive days), followed by a 28-day break and then the start of adjuvant TMZ (150 mg/m² orally or intravenously for 5 consecutive days during the first 28-day cycle, followed by 200 mg/m² orally or intravenously for 5 consecutive days during the first 28-day cycle for a maximum of 6 cycles). Diffusion and standard anatomical MRI were performed within 10 weeks after the start of RT + TMZ or within 4 weeks from the end of RT + TMZ—just before adjuvant TMZ.