Table 1.

Genetic variants associated with disease manifestations.

Disease phenotypes	Genetic variants associated with related SNPs
Skin involvement	ITGAM rs1143679 FCGR2A rs1801274 IL-6 174G/C VDR rs1168268
Serositis	TRAF3IP2 rs33980500, rs13190932, and rs13196377 PTPN2 rs2542151
Kidney involvement	HLADR2, HLADR3 rs2187668  STAT4 rs7574865, rs11889341, rs7568275, and rs7582694 ITGAM rs1143683, rs1143679 IRF5 rs2004640, rs2079197, and rs10488631 IRF7 rs4963128 TNFS4 rs2205960 DNAse I Q222R
Neurologic disorder	TREX1 rs922075, rs6776700, rs6442123, rs2242150, and rs11797
Joint involvement	ITGAM rs1143679 FGCR2A, FCGR3A  VDR rs3890733 Mir146a rs2910164
Hematological features	IL-21 rs907715 STK17A haplotype TAGTC
Immunologic disorders	Anti-dsDNA  HLADR2, HLADR3 rs2187668   STAT4 rs7582694, rs7574865  ITGAM rs1143679, rs9888739  IRF5 rsrs10488631 SSA/SSB  ITGAM rs1143679  IRF7 rs4963128  HCP5 rs3099855  HLADR3 rs2187668 RNP  ITGAM rs1143679 Sm  ITGAM rs7574865 aCL  HCP5 rs3099844 C3 reduction  Mir146a rs2910164 C4 reduction  TRAF3IP2 rs33980500