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Diabetic albuminuria was reduced by knockout of the ACKR2 gene at 2, 4, and 6 months of age. Urine albumin and creatinine were determined as described in Methods. ∗ indicates p < 0.05 versus OVE. Comparisons were performed by one-way ANOVA. n ≥ 12 in each OVE and OVE-ACKR2 group. For FVB n = 14,9, and 6 at 2, 4, and 6 months, respectively. For ACKR2 n = 3, 7, and 7 at 2, 4, and 6 months, respectively.
