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Renal fibrosis is reduced by knockout of the ACKR2 gene in diabetic OVE-ACKR2 mice. (a) Representative images of renal fibrosis illustrated by trichrome staining in a kidney section for each genotype. Original magnification 200x. (b) Scoring of renal fibrosis by blind counting of blue stained fibrotic regions in trichrome stained kidney sections. ∗ p < 0.02 versus OVE by one-way ANOVA. 6 sections from 3 mice per group were counted.
