Table 2.
Hepatic lipid peroxidation and serum biochemical markers in mice after 24 hours of CCl4 treatment with or without pretreatment of α-adrenergic blocker or β-adrenergic blocker.
| Parameter | Saline + CCl4
(n = 4) |
Phentolamine + CCl4
(n = 4) |
Nadolol + CCl4
(n = 4) |
|---|---|---|---|
| 4-Hydroxy-2-nonenal (4-HNE, μg/μg protein) | 0.34 ± 0.04 | 0.25 ± 0.01∗ | 0.28 ± 0.02 |
| Aspartate transaminase (AST, IU/L) | 16,695 ± 5,203 | 6,038 ± 3,320∗ | 13,571 ± 5,758 |
| Alanine transaminase (ALT, IU/L) | 14,559 ± 3,268 | 7,318 ± 3,799∗ | 10,830 ± 4,381 |
| Alkaline phosphatase (ALP, IU/L) | 131 ± 14 | 106 ± 21∗ | 140 ± 31 |
| Lactate dehydrogenase (LDH, IU/L) | 30,656 ± 9,387 | 8,994 ± 5,986∗ | 17,483 ± 10,584 |
The results are presented as mean ± SD.
∗ denotes significant differences compared with the saline + CCl4 group (p < 0.05).