Figure 4.

Ebselen reversed the CIH-induced increase in BP responses evoked by an acute hypoxic stimulus. Telemetry recordings realized in the same rat show the pressure response evoked by hypoxia (5% O₂ for 50 s), during sham conditions, after 7 days of CIH, and after additional 7 days of CIH but supplemented with Ebselen (a). Summary of the effect of Ebselen on mean arterial blood pressure (MABP, (b)) and heart rate (HR, (c)). ^∗ P < 0.05, CIH versus sham and Ebselen CIH, and Newman-Keuls after Repeated Measures ANOVA, n = 4 rats.