Fig. 1.

EP1 deletion prevents rotational asymmetry in 6-OHDA-induced Parkinsonism: The C57BL/6 WT and EP1^−/− mice were given a unilateral stereotaxic injection of 3.6 μg 6-OHDA in the medial forebrain bundle. On day 7, all mice were given a 0.5 mg/kg apomorphine injection SC, and were tested for apomorphine-induced contralateral rotations. The mice were monitored three times for a consecutive session of 5 min each immediately after the apomorphine injection. The figure shows that the rotations were significantly reduced by 47.50 ± 8.96 % in the EP1^−/− mice. Data are presented as mean ± SEM. *p < 0.01 as compared with the WT group