Table 2.
Liver laboratory parameters, cytokines and kidney retention parameters before and after ECAD
| MARS, median (IQR) | SPAD, median (IQR) | |||||
|---|---|---|---|---|---|---|
| Before | After | Difference | Before | After | Difference | |
| Bilirubin, μmol/L | 323 (255.5–372.0) | 249 (192.0–286.5) | * | 315 (249.5–389.5) | 243 (199.5–309.5) | * |
| GGT, μmol/L | 1.69 (0.805–4.567) | 1.52 (0.760–4.125) | * | 1.66 (0.760–3.960) | 1.53 (0.795–4.020) | ** |
| TBA, μmol/L | 119 (51.6–245.1) | 75 (30.9–167.0) | * | 105 (58.1–218.9) | 97 (50.7–202.4) | ** |
| ABiC, % | 67 (55.2–80.6) | 76 (67.5–90.4) | * | 66 (57.4–77.8) | 71 (60.3–81.1) | ** |
| IL-6, pg/ml | 142 (62.4–358.9) | 123 (63.0–268.8) | n.s. | 185 (94.3–369.8) | 173 (55.9–385.8) | n.s. |
| IL-8, pg/ml | 66 (46.2–100.9) | 65 (49.7–94.9) | n.s. | 70 (46.6–124.5) | 68 (45.6–108.1) | n.s. |
| Creatinine, μmol/L | 132 (85.5–186.5) | 101 (64.0–145.9) | * | 139 (79.0–201.5) | 146 (83.0–199.8) | ** |
| Urea, mmol/L | 11.6 (7.13–17.10) | 10.5 (6.60–15.30) | * | 12.8 (8.35–18.10) | 13.4 (8.93–16.88) | ** |
ECAD extracorporeal albumin dialysis, MARS Molecular Adsorbents Recirculating System, SPAD single-pass albumin dialysis, GGT γ-glutamyl transferase, TBA total bile acid, ABiC albumin-binding capacity, IQR interquartile range, IL interleukin, n.s. non-significant
*p < 0.05 significant changes within ECAD
**p < 0.05 significant differences between both devices