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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: J Pathol. 2015 Oct 1;238(2):311–320. doi: 10.1002/path.4634

Figure 1.

Figure 1

H&E images of lesions of the pancreas in the wild-type and CF pig, ferret and zebrafish. A. Wild-type newborn pig pancreas. B. CF newborn pig pancreas highlighting dilated acinus tissue (inset) filled with lightly eosinophilic secretions (arrow). Bars = 200µm (inset bars = 20µm). C. Adult pig pancreas showing normal exocrine and endocrine (arrows) pancreatic tissue. D. CF adult pig pancreas demonstrating dilated pancreatic ducts (arrows), loss of exocrine pancreatic tissue and fatty infiltration (asterisks) (Bars = 200 µm). E. Wild-type newborn ferret pancreas. Inset highlights a normal islet surround by exocrine tissue. F. CF newborn ferret pancreas with acinus dilation (arrows) Bars = 200µm (inset bars = 20µm). G. Wild-type adult ferret pancreas showing normal pancreatic islets (arrows) surrounded by exocrine pancreatic tissue. H. CF adult ferret pancreas with abundant loose fibrous connective tissue (asterisks), multifocal inflammatory cell infiltrates and multifocal islands of dilated acini and ducts filled with lightly eosinophilic secretions (arrows) (Bars = 100 µm). I. Wild-type zebrafish pancreas at 1 year post fertilization. J. cftr mutant zebrafish pancreas at 1 year post fertilization showing loss of exocrine pancreas, fibrosis and dilated pancreatic ducts (white arrows) (bars = 50 µm) (reprinted with permission) [12].