TABLE 3.
Pulmonary Histopathology Findings in Mice Aspirating Furfuryl Alcohol with and without Prior Sensitization
| Pulmonary challengea |
|||
|---|---|---|---|
| PBS | 2% furfuryl alcohol | ||
| Dermal sensitization | Acetone | Eosinophilic pneumonia 0/2 (0)b | Eosinophilic pneumonia 0/2 (3)b,c |
| Airway mucous metaplasia 0/2 (0) | Airway mucous metaplasia 2/2 (5) | ||
| 25% furfuryl alcohol | Not done | Eosinophilic pneumonia 2/2 (6.5)b | |
| Airway mucous metaplasia 2/2 (6) | |||
| 50% furfuryl alcohol | Not done | Eosinophilic pneumonia 2/2 (6)b | |
| Airway mucous metaplasia 2/2 (6) | |||
| 75% furfuryl alcohol | Eosinophilic pneumonia 0/2 (0)b | Eosinophilic pneumonia 2/2 (6.5)b | |
| Airway mucous metaplasia 0/2 (0) | Airway mucous metaplasia 2/2 (6) | ||
a
Data are presented as the number affected/number evaluated followed by the mean pathology score of all animals in that exposure.
b
Eosinophilic pneumonia includes pneumonias classified as eosinophilic and neutrophilic, pneumonias classified as histiocytic and eosinophilic, and pneumonias classified as eosinophilic and histiocytic. All pneumonia involve both bronchioles and the nearby interstitium (bronchointerstitial).
c
One mouse in this group developed multifocal mild histiocytic bronchointerstitial pneumonia with a small number of neutrophils, lymphocytes, and eosinophils as lesser contributors to the inflammation.