Table 1.

Lipophilicity and protein binding characteristics of study drugs

Study drug	Lipophilicity (logP)	Protein binding (%)
Ceftriaxone	−1.7	95
Ciprofloxacin	2.3	20–40
Caspofungin	0.1	97
Fluconazole	0.4	11–12
Gentamicin	−3.1	0–30
Meropenem	−0.6	2
Doripenem	0.7	8
Vancomycin	−3.1	55

A higher numeric value for octanol-water partition coefficient (logP) indicates greater lipophilicity [29]