Table 2.
Demographic and physiologic data at baseline after initiation of anaesthesia, mechanical ventilation and haemodynamic monitoring and before smoke inhalation and commencement of ECMO
| Group | Mean | SD | p Value | |
|---|---|---|---|---|
| Weight, kg | E24H | 48.5 | 4.6 | 0.84 |
| SE24H | 49.6 | 4.4 | ||
| Heart rate, beats/min | E24H | 116 | 13 | 0.78 |
| SE24H | 118 | 11 | ||
| Mean arterial BP, mmHg | E24H | 116.1 | 6.8 | 0.91 |
| SE24H | 115.7 | 8.1 | ||
| Mean PAP, mmHg | E24H | 24.6 | 2.8 | 0.06 |
| SE24H | 21.2 | 3.2 | ||
| CVP, cmH2O | E24H | 15.6 | 2.8 | 0.06 |
| SE24H | 12.2 | 3.2 | ||
| CCO, L/min | E24H | 5.44 | 0.93 | 0.33 |
| SE24H | 5.03 | 0.46 | ||
| SvO2, % | E24H | 78.8 | 7.1 | 0.31 |
| SE24H | 82.0 | 4.1 | ||
| PEEP, cmH2O | E24H | 8.1 | 2.6 | 0.67 |
| SE24H | 7.5 | 2.7 | ||
| Respiratory rate, breaths/min | E24H | 10.9 | 6.0 | 0.6 |
| SE24H | 12.5 | 5.2 | ||
| Fluid balance, ml | E24H | 681 | 376 | 0.11 |
| SE24H | 926 | 68 | ||
| Haemoglobin, g/L | E24H | 7.0 | 1.2 | 0.47 |
| SE24H | 7.6 | 1.7 | ||
| pH | E24H | 7.385 | 0.031 | 0.62 |
| SE24H | 7.397 | 0.052 | ||
| Body temperature, °C | E24H | 38.26 | 0.61 | 0.67 |
| SE24H | 38.13 | 0.50 | ||
| Lactate, mmol/L | E24H | 1.34 | 0.44 | 0.17 |
| SE24H | 1.07 | 0.24 | ||
| Midazolam dose, mg/h | E24H | 14.4 | 1.2 | 0.17 |
| SE24H | 15.0 | 0.0 | ||
| Urine output, ml/h | E24H | 69 | 44 | 0.87 |
| SE24H | 74 | 68 | ||
| Albumin, g/L | E24H | 37.16 | 2.53 | 0.33 |
| SE24H | 38.15 | 0.86 | ||
| Alanine aminotransferase (U/L) | E24H | 11.7 | 2.1 | 0.51 |
| SE24H | 12.4 | 1.7 | ||
| Serum bilirubin, μmol/L | E24H | 2.16 | 0.69 | 0.75 |
| SE24H | 2.03 | 0.74 | ||
| Serum creatinine, μmol/L | E24H | 88 | 15 | 0.94 |
| SE24H | 87 | 11 | ||
| Total protein, g/L | E24H | 71.7 | 6.4 | 0.78 |
| SE24H | 71.0 | 1.9 | ||
| Urine creatinine, μmol/L | E24H | 10,172 | 3798 | 0.17 |
| SE24H | 15,541 | 8009 |
BP blood pressure, PAP pulmonary arterial pressure, CVP central venous pressure, CCO continuous cardiac output, SvO2 mixed venous oxygen saturation, PEEP positive end-expiratory pressure
Data presented are derived from comparison of the results between groups: healthy sheep on extracorporeal membrane oxygenation (E24H) (n = 7), sheep with smoke inhalation acute lung injury on extracorporeal membrane oxygenation (SE24H) (n = 6)