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. 2015 Dec 25;19:449. doi: 10.1186/s13054-015-1166-4

Table 1.

Specification of the research question applying a PICO (population, intervention, comparison and outcome) model

Population Intervention Comparison Outcomes
Adult patients (≥18 years) undergoing any type of major surgery Treatment with fenoldopam in the peri-operative period Placebo Incidence of AKI Requirement for RRT post-operatively Hospital mortality Side effects (hypotension, need for catecholamine treatment)

AKI acute kidney injury, RRT renal replacement therapy